Physician developed & scientifically formulated. Each full press of the pump dispenses 20 mg of natural progesterone USP and 25 mg natural phytoestrogens. Progesta-Care Plus is formulated to contain 480 mg of natural progesterone USP and 600 mg of natural phytoestrogens per ounce. (This product and these statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.) No animals were used to test this product. Manufactured in the USA. * Should try pumping the bottle 30 to 40 times. * Remove the cap. * Before using the pump for the first time only, prime the pump by pressing the top of the pump all the way down repeatedly until the cream appears. The cream obtained from priming should be dispensed into a tissue and then discarded. The pump is now primed and is ready to use. You will not have to repeat this priming process during your treatment. * When dispensing the cream, slightly tilt the pump.